FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL
Abstract: This study was
carried out to develop matrix based transdermal patches containing Atenolol. A
2 factors (HPMC (hydroxyl propyl methyl cellulose) K4M & PVP (Polyvinyl
Pyrolidone) 3 level (23) factorial design was done using Design Expert® which
gave 13 experiments. The patches were prepared by Solvent casting method.
Propylene glycol (3%) and Tween 80 (6%) were used as plasticizer and permeation
enhancer respectively. Physicochemical characteristics and In-Vitro permeation
study of formulated transdermal patches were carried out. Contour plot
suggested 770 mg of PVP and 265 mg of HPMC K4M in Optimized formulation.
Keywords: Atenolol;
Transdermal Patches; In-Vitro permeation study; permeation enhancer; HPMC; PVP
Author: Uttam Budhathoki,
Kshitij Gartoulla, Shailendra Shakya
Journal Code: jpfarmasigg160040
