Formulation Development and Evaluation Of Chewable Tablet Of Mebendazole Nanoparticle
ABSTRACT: Mebendazole is a
benzimidazole derivative with broad spectrum anthelminthic activity andexcellent
tolerability. Orally it is rapidly absorbed and metabolized to sulfoxide and
sulfone,which may be responsible for its anthelminthic action. This research
aimed to formulatemebendazole nanoparticle chewable tablet to increase its
dissolution velocity and impactsaturation solubility.
Mebendazole nanoparticle chewable tablets (300 mg) were prepared by
directcompression. The tablets prepared by this method were evaluated by
different parameters suchas average weight, hardness, friability, disintegration,
drug content and in vitro dissolution etc.All the parameters were found within
the specifications.
The study on the dissolution profile revealed that F1 had better
dissolution rate while compared to F2, F3 and mebendazole microparticle,
respectively. Assay values were within the limits of 90% to 110%.
Keywords: Mebendazole,
Nanoparticle, Direct compression, Chewable tablets
Penulis: Muhammad Dzakwan and
Widodo Priyanto
Kode Jurnal: jpfarmasidd160512
