FORMULATION OF FLUCONAZOLE AS TOPICAL ANTIFUNGAL GELS BY MICROSPONGE BASED DELIVERY SYSTEMS
Abstract: The purpose of
present work was to formulate Fluconazole loaded microsponge-based topical
delivery system for modified release. Microsponges with varied drug–polymer
ratios were prepared by emulsion solvent diffusion technique using Ethyl
cellulose as release retard material. Prepared microsponges were studied for
particle size and physical characterization. Scanning electron microscopy (SEM)
images showed the microsponges porous and spherical in shape. The microsponges
were then incorporated in carbopol gel and evaluated for pH, viscosity,
spreadability, drug content, in-vitro release. The In vitro drug release showed
that microsponges with 1:1.5 drug–polymer ratios (F3) were more efficient to
give sustained release of 74.2% at the end of 8 hr. All the microsponge gel
formulations (i.e.F1- F10) showed better results like pH between 6.5-7.0,
viscosity between 25,030-47,390 cps, spreadability 2-4 cm/s and drug content of
76.20±0.02% to 96.41±0.01%. Hence, the
fabricated microsponge based formulation of Fluconazole would be anticipation
and promising substitute to conventional therapy of skin infections.
Keywords: Fluconazole,
Microsponge, Ethyl cellulose, Scanning electron microscopy and Zero order
kinetics
Author: Swamykannu Dinesh
Mohan, Vangadari Rama Mohan Gupta
Journal Code: jpfarmasigg170022
