Formulation of Instant Granule Containing Nano Calcium from the Shell of Freshwater Mussels (Anodonta woodiana) for Autism Children
Abstrak: The small particle
size of nano calcium from freshwater mussels shell will tend to increase the
absorp- tion of calcium by human’s body and will be very well consumed by
children with special needs to suppress hyperactivity disorders that caused by
mercury. This study aimed to create and determine the best instant granule
formulation containing nano calcium from freshwater mussels shell. The research
method began with the manufacture of freshwater mussels shell powder and isolated
nano calcium. Nano calcium was tested for its solubility in acid. The granule
formula was made with stevia varia- tions. Instant granule evaluation included
granule ow test, rest angle, compressibility, water content, solubility,
hedonic test, and calcium bioavailability. The results showed that nano calcium
was soluble in 1:1 ratio of citric and tartrate acids, so that each formula
needs 1.2% citric and 1.2% tartrate acids. Based on the avor, aroma, and
texture, the most preferred granule formula contained 600 mg nano calcium, 60
mg citric acid, 60 mg tartaric acid, 400 mg stevia each sachet weighing 5 g.
The best in- stant granule evaluation showed that the ow rate was 4.253 g/sec,
33.90 rest angle, 4.65% compress- ibility, 2.21% water content, soluble time 58
second and calcium bioavailability was 100%.
Key words: Calcium
bioavailability, detoxi cation, freshwater mussels, instant granule, nano cal-
cium
Penulis Tri Aminingsih, Sata
Yoshida Srie Rahayu, Yulianita
Kode Jurnal: jpfarmasidd180234
