Formulation of Metformin HCl Floating Tablet using HPC, HPMC K100M, and the Combinations
Abstrak: Floating tablet is
one of the most suitable dosage forms that used for delivering long term drug
release. The objective of this study was to evaluate Hydroxypropyl cellulose
(HPC), Hydroxypropyl Methyl Cellulose (HPMC) K100M, and the combination as
matrix in manufacturing floating tablets. Metformin HCl, an anti-diabetic, was
used as a drug model. Metformin HCl floating tablet was manufactured by wet
granulation method in three formulas using variation of matrix, which were 40%
of HPC (F1), 40% of HPMC K100M (F2), combination of 20% HPC and 20% HPMC K100M
(F3). Prior to tablet compaction, evaluation for granules were done which
included moisture content, angle of repose using, bulk and tapped density,
Hausner ratio, and compressibility. The evaluations of floating tablet were
physical properties, floating ability, and in vitro drug release. The average
of floating lag time for F1, F2, F3, were 7 minutes 13 seconds; 5 minutes 27
seconds; and 14 minutes 5 seconds, respectively. In addition, the floating time
for F1 was 3 hours 16 minutes whereas F2, F3 were more than 48 hours. F2 showed
the best floating ability to retain the drug release, which was 84.68% over 8
hours, while F1 and F3 were completely dissolved less than 6 hours.
Kata Kunci: floating tablet; HPC;
HPMC K100M; combination; metformin HCl
Penulis: Lili Fitriani, Rudi
Abdillah, Elfi Sahlan Ben
Kode Jurnal: jpfarmasidd170382
