GAMBARAN INTERAKSI OBAT HIPOGLIKEMIK ORAL (OHO) DENGAN OBAT LAIN PADA PASIEN DIABETES MELITUS (DM) TIPE II DI APOTEK IMPHI PERIODE OKTOBER 2014 SAMPAI MARET 2015
Abstract: Increasing
complications of diabetes mellitus (DM) have tendency to amount of drug use,
which can increase the risk of drug interaction. Drug interaction is a
situation arising of administrations more than one drug at the same time that
effects each drug can be interfere each other and or both are mutually and or
undesirable side effect may a rise which could potentially harm and or doesn’t
give clinically significant effect. This research aims to determinate the
potential interactions and mechanisms of drug interactions and impacts based on
the severity of the effect of therapy in patients type II of diabetes mellitus
(DM) at Imphi’s Pharmacy in the period October 2014 until March 2015. The
research used descriptive evaluative and retrospective method based on recipe
sheets. Data analysis have done by screening of drug interaction and using drug
interaction from software lexicomp and drug interaction stockley. The results
showed that there are 28 recipe sheets (16,37%) from 171 recipe sheets of 110
patients that potentially occur pharmacodynamic mechanism of drug interaction
with as many as 36 events (64,29%) as well as the mechanisms of drug
interaction based on the severity of the effect of moderate kind of therapy as
much as 40 events
Keywords: drug interaction,
oral hypoglycemic drug, type II of diabetes mellitus (DM)
Penulis: Aries Meryta
Kode Jurnal: jpfarmasidd150544
