Gastric Ulcer Healing Effect of Bangle (Zingiber cassumunar (Roxb.)) Rhizome Extract in Aspirin-induced Rats Model
Abstrak: In the
gastrointestinal system, gastric ulcers are one of the common serious diseases.
The pathophysiology of gastric ulcer is an imbalance between aggressive and
mucosal defense factor. Imbalance between aggressive and mucosal defense factor
have contribution against developed of gastric ulcer disease. The objective of
the research was to evaluate gastric ulcer healing effect of Bangle (Zingiber
cassumunar (Roxb.) rhizome extract in aspirin-induced rats model. Antiulcer
activity of Bangle rhizome extract was evaluated by several parameters
involving gastric acidity, number of ulcers, diameters of ulcers, ulcer index,
and healing ratio. Doses level of Bangle rhizome extract which used in this
study such as 50 mg/kg and 100 mg/kg, respectively. Histopathological of the
stomach was performed using hematoxylin-eosin stained. The results of study
showed that groups which given Bangle rhizome extract have signi cant effect in
gastric acidity, number of ulcers, diameters of ulcers, ulcer index, and
healing ratio compared to the control group. Histopathological study of the
stomach ulcers showed tissues regeneration in group were treated by Bangle
rhizome extract compared to the control group. It can be concluded that from
the experimental study of Bangle (Zingiber cassumunar (Roxb.)) rhizome extract
have potential antiulcer activity in aspirin-induced rats model.
Keywords: Zingiber cassumunar
(Roxb.), Extract, Ulcer, Aspirin
Penulis: Ari Yuniarto, Elis
Susilawati, Toni Abdul Rahman, Finna Setiawan, Dadang Juanda
Kode Jurnal: jpfarmasidd170598
