α-Glucosidase Inhibitory Activity and Formulation of Solid Lipid Nanoparticle Containing Ethanol 70% Standardized Extract of Kumis Kucing Leaves (Orthosiphon stamineus Benth.)
Abstract: Kumis kucing leaves
(Orthosiphon stamineus Benth.) are one type of plants that is able to inhibit
the activity of α-glucosidase enzyme. This study aims to formulate Solid Lipid
Nanoparticlefrom ethanol 70% standardized extract of kumis kucing leaves and
which give α-glucosidase enzyme inhibitory activity. The result of SLN
characteristic for particle size of formula I, II and III shows theresult of
51,60 nm; 12.81 nm; 11.87 nm and zeta potential of formula I, II and III show
the results-27.67; -10,7; -15.0, respectively. The results of the α-glucosidase
enzyme inhibitory activity of thestandardized extract, SLN formula I, II and
III respectively showed IC50 of 132.9 ppm; 130.3 ppm;131.4 ppm; 132.2 ppm and
Acarbose as comparison showed IC50 of 50.0 ppm. Data processing usingt-test
statistically at α = 0,05 showed that extract and SLN of formula I had signifi
cant difference, thus the best SLN formula was formula I with concentration of
tween 80 and propylenglycol of 6% and 10%.
Keywords: kumis kucing leaves,
standardized extract, nanoparticle, solid lipid nanoparticle
Penulis: RISMA MARISI TAMBUNAN, WINDA DWI JULIYANT
Kode Jurnal: jpfarmasidd180052
