HEPATOPROTECTIVE EFFECT OF FOREST HONEY ON CARBON TETRACHLORIDE INDUCED FEMALE WISTAR RATS
Abstract: Hepatoprotective
effect study of forest honey had been conducted on a female rat induced with
carbon tetrachloride (CCl4). The study aimed at obtaining the scientific data
and the evidence of forest honey as hepatoprotective agent on the rat. The
study was a true experimental study with a single factor completely randomized
design. Thirty rats were randomly divided into six groups (n=5). Group I
received carbon tetrachloride 2.0 mL/kgBW intraperitoneally, group II received
olive oil 2.0 mL/kgBW intraperitoneally, group III received forest honey 8.1
mL/kgBW (6 days, peroral), groups IV, V, VI were given forest honey 3.6, 5.4,
8.1 mL/kgBW (6 days, peroral) and intraperitoneal induction of carbon
tetrachloride 2 mL/kgBW on seventh day. The blood sample of all rats were taken
for ALT-AST measurement and their liver were sampled for histological
examination of the liver cell. Groups I and III on the seventh day, group II on
the second day, groups IV,V,VI on the eighth day. The result showed that a
forest honey can be used as a hepatoprotective agent on the female rat Wistar
strain induced by carbon tetrachloride 2 mL/kgBW with doses 3.6, 5.4, 8.1
mL/kgBW.
Keywords: ALT-AST; carbon
tetrachloride; forest honey; liver histopathology
Penulis: Yunita Linawati
Kode Jurnal: jpfarmasidd180172
