IDENTIFICATION OF PHYSICAL INTERACTION IN BINARY SYSTEMS OF ACYCLOVIR – SUCCINIC ACID
ABSTRACT: Acyclovir, a
guanosine analogue antiviral drug with low solubility of water. Due to its poor
solubility and permeability, causes low oral bioavailability. Objective: The
aim of this research is to investigate the physical interaction in binary systems
acyclovir-succinic acid (AS). Methods: The msystem was prepared by solvent
evaporation method. Results: Thermogram Differential Scanning Calorimetry
showed endothermic peaks at 172.68oC (ethanol) and 171.84oC (methanol). The
Powder X-Ray Diffraction (PXRD) pattern of AS was different from pure component
and physical mixtures. Furthermore, physical characterization showed the binary
system of AS have unique crystal habit by polarization microscope. Conclusion:
New crystalline phase is formed from the interaction between acyclovir and
succinic acid by solvent evaporation method using ethanol and methanol.
KEYWORDS: physical
interaction, acyclovir, succinic acid, binary systems
Penulis: Agnes Nuniek Winanta,
Dwi Setyawan, Siswandono
Kode Jurnal: jpfarmasidd160729
