INJEKTABEL KOMPOSIT HYDROKSIAPATIT-GELATIN SEBAGAI SISTEM PENGHANTARAN ALENDRONAT
ABSTRACT: Bisphosphonates,
such as alendronate (ALE), have been known to be effective in the treatment of
bone cancer and osteoporosis. However, it has been reported that the systemic
administration of ALE causes a considerable side effect. Thus, the formulation
injectable bone substitute (IBS) for local administration of ALE, which
functions as drug delivery system (DDS) as well as filling agent in
osteoporosis-induced bone fracture, is needed. Objective: To establish the
biodegradable and biocompatible formulation for ALE in injectable form which supports
the drug delivery system and acts as filling agent in bone fracture. Methods:
Hydroxyapatite (HA) was added to the mixture of gelatin and hydroxypropyl
methyl cellulose (GEL-HPMC). ALE was added to the mixture and semisolid form
was prepared for granulation. The dried granule, as injectable matrix, was
grinded and mixed with appropriate amount of Na2HPO4. Results: Porosity of
injectable form was higher than those of granule form. Injectable semisolid
form was produced by adding 0.8 mL Na2HPO4 on each gram of granule with 10-12
min setting time. MTT assay showed that matrix was biocompatible showed by more
than 100% viability. In vitro dissolution study showed that ALE was slowly
released in more than 20 days. Conclusions: The formula of IBS using HA-GEL-HPMC
may act as an effective drug delivery system for local administration of ALE in
bone fracture.
KEYWORDS: hydroxyapatite,
gelatin, HPMC, alendronat, Na2HPO4, DDS (Drug Delivery System)
Penulis: Aniek Setiya
Budiatin, Junaidi Khotib, Didik Hasmono, Samirah -
Kode Jurnal: jpfarmasidd160725
