Interaction Study, Synthesis and Characterization of Molecular Imprinted Polymer Using Functional Monomer Methacrylate Acid and Dimethylamylamine as Template Molecule
Abstract: The research related
to the interaction study, synthesis and characterization of molecular imprinted
polymer using dimethylamylamine (DMAA) as the template molecule and the
functionalmonomer methacrylate acid has been conducted. Molecular Imprinted
Polymer (MIP) is a separation method made by the molecule template in the
polymer matrix followed by removing the template molecule by washing for giving
the permanent framework groove. The MIP was made by mixing the DMAA as the
template molecule, with the methacrylate acid as the functional monomer, and
theethylene glycol dimethacrylate (EGDMA) as the crosslinker with ratio of
1:6:20. Porogen solventsused were the chloroform and the initiator
azobisisobutyronitrile (AIBN). The crystal MIP and theNIP without the DMAA were
characterized using Infrared Spectrophotometer (FTIR), and the result showed
that there have been diff erences among the MIP, the NIP and the MIP after
being extracted. The characterization using Scanning Electron Microscope (SEM)
showed that the NIP as the comparison having fl at morphology, while the MIP
having irregular morphology and less pores. Then the MIP after being extracted
has irregular, rough morphology and a lot of pores. The result reveals the
interaction between the DMAA and the methacrylate acid that is the hydrogen
bonded with the Gibbs free energy obtained is -5.434 j/mol. The imprinting
factor of 2,353 is obtained. The highest desorption descendingcapacity is
chloroform with the MIP 738% better. For the MIP and NIP methanol, it is found
that the MIP is 123% better. Then the MIP which is desorbed by the chloroform
is better 602% than the MIP resorbed by the methanol, and the ethyl acetate
cannot desorb the DMAA.
Keywords: DMAA, MIP, SEM,
FTIR, Gibbs free energy
Penulis: Saeful Amin, Sophi
Damayanti, and Slamet Ibrahim
Kode Jurnal: jpfarmasidd180041
