KOMBINASI EKSTRAK ETANOL DAUN KEMANGI (Ocimum bacilicum L.) DAN DAUN SALAM (Syzygium polyanthum (Wight) Walp) SEBAGAI ANTIINFLAMASI PADA TIKUS (Rattus norvegicus) JANTAN YANG DIINDUKSI KARAGEN
Abstrak: Inflammation is a
normal protective response to tissue injury caused by physical trauma that
could damage characterized by symptoms such as pain (dolor), heat (kalor),
redness (rubor), swelling (tumor) and functional changes (fungsiolaesa). This
research aimed to determine the anti-inflammatory effects of the ethanol
extract combination of kemangi folium (Ocimum bacilicum L.) and salam folium
(Syzygium polyanthum (Wight) Walp) in male rats (Rattus norvegicus) induced
carrageen. This research used 15 rats divided into 5 groups: group I Na CMC
(Naïve), group II Sodium Diclofenac (negative), group III was administered the
ethanol extract of kemangi folium and
salam folium with dose 125:125 mg/kgBW, group IV with dose of 125:75 mg/kgBW
and group V with dose 250:75 mg/kgBW. The entire of administration was done
orally. The measurement of male rat foot was performed every 30 minutes to 150
minutes. The data were statistically analyzed using One Way ANOVA followed by
Post Hoc LSD test. The results showed that the ethanol extract of Kemangi
folium with dose of 250 mg/kgBW and the ethanol extract of Salam folium with
dose of 75 mg/kgBW had the effect of decreasing the edema volume of the rat
foot effectively the same as anti-inflammatory drugs NSAID where the results of
statistical analysis were obtained significance (p>0.05).
Kata Kunci: mInflammation, Kemangi Folium, Salam Folium, Sodium
Diclofenac
Penulis: sukmawati, Rachmat
Kosman, Nurwasi Saharuddin
Kode Jurnal: jpfarmasidd180137
