Modulatory effect of Drosera peltata J.E.Sm on development of metabolic syndrome in tumor bearing mice
Abstract: The purpose of the
study conducted was to know the extent of protection over the cancer associated
metabolic syndrome development after administration of ethanol and aqueous
extracts of Drocera peltata against Dalton’s ascites lymphoma (DAL) and
Ehrlich's Ascites Carcinoma (EAC) bearing mice. Animals were divided into
thirteen groups with a normal control, EAC control, DAL control, two groups
with standard drug 5-Flurouracil 20mg/kg+ DAL & EAC and eight groups with 250
and 500 mg/kg of ethanol and aqueous extracts of D.peltata + EAC & DAL, for
respective cell lines. After 24 hours of both tumor cell inoculation, animals
were treated with extracts,once in a day for 14 days continuously. The
indicators for the development of metabolic syndrome such as changes in blood
glucose, serum hormone and lipid profile were found with both cell line bearing
mice. Both ethanol and aqueous extracts of D.peltata at doses of 250 and
500mg/kg significantly reduced the elevated blood glucose, hormonal and lipid
profile changes. These results confirmed that ethanol and aqueous extracts can stabilize the tumor induced hormonal,
blood glucose and lipid profile changes in tumor bearing mice. This effect might
be due to the presence of pharmacologically active phytoconstituents in
extracts.
Keywords: Metabolic syndrome;
Ehrlich's Ascites Carcinoma; Dalton’s ascites lymphoma; Drocera peltata;
anticancer
Penulis: Raju A, Seeja S Raj,
Christina AJM
Kode Jurnal: jpfarmasigg160039
Artikel Terkait :
Jp Farmasi gg 2018
- The Formulation of Pacing (Costus speciosus) Extract Tablet by Using Avicel®Ph 200 As Filler-Binder and Amylum As Disintegration Agent
- In Vitro Evaluation of Anti-Inflammatory and Anti-Diabetic Potential Effects of Euphorbia Tithymaloides Ethanol Extract
- Hypoglycemic Activity and Pancreas Protection of Combination Juice of Mengkudu (Morinda citrifolia Linn.) Juice and Temulawak (Curcuma xanthorrhiza Roxb.) Juice on Streptozotocin-Induced Diabetic Rats
- The Antihyperglycemic Activity of Ethanol Extract of Trigonella foenum-graecum L. and Its Effect on the GLUT-2 Expression of Streptozotocin-NicotinamideInduced Rats
- The Effects of Dual Antiplatelet Post Percutaneous Coronary Intervention on Percentage of Aggregation In Myocardial Infarction Patients with Diabetes Mellitus and Non Diabetes Mellitus
- Formulation and Evaluation of Glipizide Tablets Utilizing Hibiscus Rosasinensis Leaves Mucilage
- NATIONAL HEALTH COVERAGE SYSTEM : PHARMACISTS AND JKN PARTICIPANT SATISFACTION IN PRIMARY HEALTH FACILITIES
- Validation and Quantification of Theophylline and Salbutamol using Ion Pair Liquid Chromatography
- SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2-[(SUBSTITUEDPHENYL)-5-(1-PHENYL-3-(PIPERAZINYL)PYRIDO[3,2-f]QUINAZOLIN-4(1H)-YL]-1,3,4-THIADIAZOLES
- EVALUATION OF THE EFFECTIVENESS OF FREE NICOTINE PATCH THERAPY IN A CHARITY CLINIC FOR SMOKING CESSATION
- Ameliorative effects of vitamins C and E on tenofovir/nevirapine-induced hepatorenal oxidative stress in albino rats
- FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL
- COMPARATIVE STANDARDIZATION OF MARKETED FORMULATIONS OF FERMENTED BIOMEDICINE – ARJUNARISTHA
Jp Farmasi gg 2016
- NATIONAL HEALTH COVERAGE SYSTEM : PHARMACISTS AND JKN PARTICIPANT SATISFACTION IN PRIMARY HEALTH FACILITIES
- Validation and Quantification of Theophylline and Salbutamol using Ion Pair Liquid Chromatography
- SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2-[(SUBSTITUEDPHENYL)-5-(1-PHENYL-3-(PIPERAZINYL)PYRIDO[3,2-f]QUINAZOLIN-4(1H)-YL]-1,3,4-THIADIAZOLES
- EVALUATION OF THE EFFECTIVENESS OF FREE NICOTINE PATCH THERAPY IN A CHARITY CLINIC FOR SMOKING CESSATION
- Ameliorative effects of vitamins C and E on tenofovir/nevirapine-induced hepatorenal oxidative stress in albino rats
- FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ATENOLOL
- COMPARATIVE STANDARDIZATION OF MARKETED FORMULATIONS OF FERMENTED BIOMEDICINE – ARJUNARISTHA
- INFLUENCE OF POMEGRANATE JUICE ON THE CYP3A4-MEDIATED METABOLISM AND P-GLYCOPROTEIN MEDIATED TRANSPORT OF SAQUINAVIR IN VIVO AND EX VIVO MODELS
- ANTIOXIDANT ACTIVITY OF DRIED STRAWBERRY JUICES (Fragaria vesca L.) EMULGEL PREPARATION USING CANDLENUT OIL AND IT’S DIFFUSION
- ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF KALANCHOE PINNATA LEAVES IN ALLOXAN INDUCED HYPERGLYCAEMIC RATS
- MONOSODIUM GLUTAMATE EXPOSURE AT EARLY DEVELOPMENTAL STAGE INCREASES APOPTOSIS AND STEREOTYPIC BEHAVIOR RISKS ON ZEBRAFISH (DANIO RERIO) LARVAE
- THE EFFICACY OF DIFFERENT ORAL MAGNESIUM SUPPLEMENTS FOR MIGRAINE PREVENTION: A LITERATURE REVIEW
- OPTIMIZING STRUCTURE-BASED VIRTUAL SCREENING PROTOCOL TO IDENTIFY PHYTOCHEMICALS AS CYCLOOXYGENASE-2 INHIBITORS
- FORMULATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM OF BOVINE SERUM ALBUMIN USING HLB (HYDROPHILIC-LYPOPHILIC BALANCE) APPROACH
- CYTOTOXIC AND ANTI-VIRAL ACTIVITY OF Acacia catechu ON HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS
- SYNTHESIS AND ANALGETIC ACTIVITY EVALUATION OF 4-[N-(4-HYDROXYPHENYL)CARBOXYMIDOYL]-2-METHOXYPHENOL
- SYNTHESIS AND SCREENING OF SOME AZOMETHINES BEARING METHYL SALICYLATE MOIETY FOR ANTIBACTERIAL ACTIVITIES
- AN LC- MS/MS METHOD FOR THE DETERMINATION OF OMEPRAZOLE ON PROTON PUMP INHIBITOR IN HUMAN PLASMA
- ANTI-OXIDANT AND ANTI-DIABETIC ACTIVITIES OF ETHANOLIC EXTRACT OF Primula denticulata FLOWERS
- ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF TAXILLUS TOMENTOSUS PLANT ON ETHYLENE GLYCOL AND AMMONIUM CHLORIDE INDUCED UROLITHIASIS IN WISTAR RATS
- PHYTOCHEMICAL CONSTITUENTS AND HYPOGLYCEMIC EFFECT OF GYMNEMIC ACID EXTRACTS FROM BIG AND SMALL LEAF VARIETIES OF Gymnema Sylvestre R.Br
- FORMULATION DEVELOPMENT AND CHARACTERIZATION OF TEA TREE OIL LOADED ETHOSOMES
- DETERMINATION OF SIBUTRAMINE ADULTERATED IN HERBAL SLIMMING PRODUCTS USING TLC DENSITOMETRIC METHOD
- PHYSICAL CHARACTERIZATION OF IBUPROFEN-STEARIC ACID BINARY MIXTURE DUE TO COMPRESSION FORCE