Modulatory effect of Drosera peltata J.E.Sm on development of metabolic syndrome in tumor bearing mice
Abstract: The purpose of the
study conducted was to know the extent of protection over the cancer associated
metabolic syndrome development after administration of ethanol and aqueous
extracts of Drocera peltata against Dalton’s ascites lymphoma (DAL) and
Ehrlich's Ascites Carcinoma (EAC) bearing mice. Animals were divided into
thirteen groups with a normal control, EAC control, DAL control, two groups
with standard drug 5-Flurouracil 20mg/kg+ DAL & EAC and eight groups with 250
and 500 mg/kg of ethanol and aqueous extracts of D.peltata + EAC & DAL, for
respective cell lines. After 24 hours of both tumor cell inoculation, animals
were treated with extracts,once in a day for 14 days continuously. The
indicators for the development of metabolic syndrome such as changes in blood
glucose, serum hormone and lipid profile were found with both cell line bearing
mice. Both ethanol and aqueous extracts of D.peltata at doses of 250 and
500mg/kg significantly reduced the elevated blood glucose, hormonal and lipid
profile changes. These results confirmed that ethanol and aqueous extracts can stabilize the tumor induced hormonal,
blood glucose and lipid profile changes in tumor bearing mice. This effect might
be due to the presence of pharmacologically active phytoconstituents in
extracts.
Keywords: Metabolic syndrome;
Ehrlich's Ascites Carcinoma; Dalton’s ascites lymphoma; Drocera peltata;
anticancer
Penulis: Raju A, Seeja S Raj,
Christina AJM
Kode Jurnal: jpfarmasigg160039
