Mulberry Leaves (Morus alba) for Diabetes Mellitus: Acute Toxicity Test in Male Wistar Rats
Abstrak: Diabetes mellitus
(DM) is a chronic disease which becoming health community problem in the world.
DM patients can be treated by antidiabetic drugs throughout their lifetime.
Therefore, to alleviate the concern for the side e ect, it is important to have
an alternative therapy which has same e ect but less side e ect. One of
alternative therapies which has been known for a long time ago is Mulberry
leaves (Morus alba). For something to be clinically used as an alternative
therapy, e ective and lethal dose should be known. Here we tried to discover
the lethal dose (LD50) and the liver morphological changes, using the e ective
dose that had been known from previous study. In our experiment, we used Morus
alba leaves infusion and 25 male Wistar rats. These rats were divided into 1
control group and 4 groups treatment dosage, 0.3, 3, 30, and 300 grams/kg
bodyweight. We observed the mortality in 7 days and examined the liver
morphological changes. From this study, we conclude that 300 grams/ kg
bodyweight or 48 grams/kg bodyweigtht in human was pseudolethal dose in male
Wistar rats. We did not found any signi cant liver morphological changes.
Therefore, we can categorize Morus alba as a harmless alternative therapy.
Key words: Alternative
therapy, diabetes mellitus, liver morphological changes, lethal dose, Morus
alba
Penulis: Rena Nurita, Anisa
Vitriana, Isni Maulina Sukmara, Nurul Utami, Maryam, Fathul Huda, Vycke
Yunivita
Kode Jurnal: jpfarmasidd180228
