OPTIMASI FORMULA EKSTRAK JAHE MERAH (Zingiber officinale) DENGAN METODE KEMPA LANGSUNG MENGGUNAKAN ANALISIS SIMPLEX LATTICE DESIGN
Abstract: Processing of
medicinal plants into the appropriate dosage form can ensure security during
use. It is a motivation in making acceptable dosage form which is easy and
convenient to use, especially the manufacture of ethanol extract red ginger
tablets using a combination of starch 1500 and amprotab.The study begins with
the manufacture of dry extract of red ginger. Optimization of making tablets
using a combination of starch 1500 and disintegrator with simplex lattice
design using three formulas is done by direct compaction method. Further
testing on the tablet hardness, friability and disintegration time.The results
showed starch 1500 has a greater influence increase hardness and disintegration
time of tablets, as well as lowering the fragility of the tablet. While the
interaction of starch 1500 and disintegrator has no effect on the physical
tablet. The optimum proportion of the combination of starch 1500 and
disintegrator meet the physical requirements of tablets with a ratio of 4: 6
with 7.99 kg hardness, the friability of 0.32% and disintegration time of 2.42
minutes
Keywords: extract red ginger, simplex lattice design, direct
compaction method
Penulis: Hayatus Sa'adah
Kode Jurnal: jpfarmasidd150519
