OPTIMASI FORMULA MATRIKS KITOSAN DENGAN METILSELULOSA PADA PELEPASAN TERKENDALI SEDIAAN GRANUL TEOFILIN
Abstract: The in vitro study
was carried out on the release of active ingradient theophylline from granules
prepared by moist granulation method. The granule matrix was prepared from the
mixture of chitosan isolated from SwaIIo shrimp (Metapenaeus monoceros) (in
accordance with the Protan Laboratories, Inc standard requirement) and
methylceliuiose 1500 cps. The granules were filled into 850 mg capsules
containing 200 mg theophylline. The maximum weight of chitosan and
methylcellulose for each capsule was determined by factorial design 22.The
result showed that, when the amount of chitosan was kept constant, an increase
in the amount of methylcellulose will increase the release rate of theophylline
from granules. The optimum weight of chitosan and methyIceIIuIose are 609.24 mg
and 20.00 mg, respectively for one capsule.
Keywords: theophylline,
chitosan and methylcellulose
Penulis: Suprianto
Kode Jurnal: jpfarmasidd150530
