OPTIMASI POLIVINILPIROLIDON DAN CARBOPOL PADA SEDIAAN PATCH DISPERSI PADAT PIROKSIKAM
Abstract: Piroxicam, a non
steroidal anti inflammatory drugs (NSAID), is an oxicam derivative which can be
used for treatment of various rheumatic diseases, such as rheumatoid arthritis
and osteoarthritis. Piroxicam patch is an affective approach evading
piroxicam’s side effect such as peptic ulcer and first pass metabolism. One of
the patch components is polymer that the function is to control the speed of
drug release from the patch. The aims of this study were to determine the
optimum formula of a combination of polyvinylpyrolidone (PVP) and Carbopol to %
moisture content (MC) and the flux release in solid dispersion piroxicam patch
using Simplex Lattice Design. Piroxicam was prepared in the form of a solid
dispersion in PEG 4000 to increase its solubility. The design formula of solid
dispersion piroxicam patch made with the ratio PVP : Carbopol, that were 1 : 0;
0.5 : 0.5; 0 : 1. The optimum formula was chosen with the ratio PVP : Carbopol,
1: 0, which gave the best result of % MC and flux release. The result of % MC
was 6.91% and the result of flux release was 35.543 µg/cm2.menit1/2.
Keywords: solid dispersion
piroxicam patch, PVP, Carbopol
Penulis: Dwi Nurahmanto, Friska
Wira Sabrina, Lidya Ameliana
Kode Jurnal: jpfarmasidd170167
