Pembuatan dan Karakterisasi Dispersi Padat Nifedipin dengan Poloxamer 188 Menggunakan Metode Peleburan
Abstrak: Nifedipin is a poorly
water soluble calcium channel blocking agent. Solid dispersion is one of
several pharmaceutical technologies that enhance the bioavailability of poorly
water-soluble drugs. The objective of
this study was to prepare and characterize nifedipin-poloxamer 188 solid
dispersion by fusion method. Combination of nifedipin and poloxamer 188 for F1,
F2 and F3 were 1:9, 2:8 and 3:7 respectively.
The physical mixture and solid dispersions were characterized for
particles size distribution, drug-carrier interaction, drug content and
dissolution rate. The physicochemical characterization showed a specific
characterized of solid dispersion. As
indicated from X Ray Diffractograms, DTA thermograms and SEM photographs,
nifedipin was in the amorphous form and
entrapped in polymer matrix. FTIR results proved no chemical interaction
between nifedipin and poloxamer 188. SEM images showed a new morphology of
solid dispersions compare with pure drug and physical mixture. The dissolution
rate was increased with increasing polymer concentrations. F1 showed the
highest dissolution rate among all formulas. Statistic analysis showed a
significant differences (P<0.05) of dissolution efficiency among all
formulas.
Kata Kunci: Nifedipin;
Poloxamer 188; Solid Dispersion; Fusion Method
Penulis: Rina Wahyuni, Auzal
Halim, Sri Oktavia, Rahmi Purwaningsih
Kode Jurnal: jpfarmasidd160627
