Pembuatan Kafein Salisilat Secara Semisintetis Dari Bubuk Kopi Olahan Tradisional Kerinci
Abstrak: The caffeine
contained in coffee powder processed traditionally taken in Kerinci can be
isolated, crystallized and made into a caffeine salicylate. Isolation of
caffeine conducted through the coffee powder with water extraction,
fractionation with methylene chloride, and crystallized using acetone and
petroleum ether. The crystallization process is obtained of caffeine powder
which is then reacted with salicylic acid, caffeine salicylate formed by using
the solvent toluene and petroleum ether. Identification of caffeine powder and
caffeine salicylate include: organoleptic, melting range, color reaction, the ultraviolet
spectrum, infrared spectrum and thin layer chromatography. The identification
caffeine results meet the requirements listed in the Indonesian Pharmacopoeia V
edition of 2014. The results of
determining the wavelength of maximum absorption of caffeine powder isolation
results was 276 nm, caffeine salicylate 243 & 307 nm. Rf values obtained
from thin layer chromatography test for caffeine is 0.30 and caffeine
salicylate 0.36.
Kata Kunci: Isolation;
Crystallized; Caffeine; Caffeine Salicylate
Penulis: Sestry Misfadhila,
Zulharmita, Deni Hardian Siska
Kode Jurnal: jpfarmasidd160625
