PENGARUH ISOPROPIL MYRISTAT SEBAGAI BAHAN PENINGKAT PENETRASI TERHADAP LAJU DIFUSI KRIM PEMUTIH EKSTRAK ETANOL DAUN MURBEI (Morus alba L)
Abstract: The research has
conducted research on the effectiveness of isopropyl myristat as a penetration
enhancer on the diffusion rate of whitening cream mulberry leaf extract (Morus
alba L) in vitro. This study aims to determine the effect of the use of isopropyl
myristat. Mulberry leaf extract cream made with varying concentrations
respectively 3%, 4%, 5% Isopropyl myristat as penetration enhancers made into 3
formulas (F1-F4) with the F1 without penetration enhancers. Evaluation of
stability before and after accelerated storage includes observation of the
organoleptic, emulsion type determination, measurement of pH, and viscosity.
The evaluation results indicate four physically stable formula. In vitro
diffusion studies conducted by Franz diffusion cells and footage is measured at
a wavelength of 367.4 nm. The results of diffusion studies show that formula
with the highest diffusion rate of 0.024 µg/minute on F4 (5% isopropyl
myristat).
Keywords: Mulberry Leaves,
Isopropyl myristat, Diffusion Test
Penulis: Nurul Arfiyanti Yusuf,
Aisyah Fatmawaty
Kode Jurnal: jpfarmasidd170110
