Pengaruh Pemberian Ekstrak Etanol Herba Ceplukan (Physalis angulata L.) Terhadap Gangguan Fungsi Ginjal Mencit Putih Jantan
Abstrak: The research on this study aims determine the effect of
ethanol extract of Ceplukan to renal impairment of white male mice. This plant
has many major content of flavonoid and polyphenol which is an antioxidants..
The study is conducted by five treatments i.e. negative control, positive
control, dose 375 mg/kgBW, 750 mg/kgBW, and 1,500 mg/kgBW. All groups were
induced by gentamicin for 7 days. Serum creatinin level and renal
histopathology is determined on days 8 and 16. Serum creatinine level is
analyzed by one way ANOVA statistical analysis. It show that there is
significant differences between each group (p˂0,05). Renal histopathology
analysis shows at doses 1,500 mg/kgBW there are more widespread expansion of
the urinary space, repair of glomerulus cells which is damaged, decrease epithelial cells which is
enter into the tubular lumen. It can be concluded that the ethanol extract of
ceplukan can repair renal impairment.
Kata Kunci: Physalis angulata
L.; Renal; Histopathology
Penulis: Sri Oktavia, Surya
Dharma, Anton Yarman
Kode Jurnal: jpfarmasidd160612
