PENGARUH PERBEDAAN CHEMICAL PENETRATION ENHANCER PADA PENETRASI TRANSDERMAL PATCH PROMETAZIN HCL
Abstract: This research aims
is to create a promethazine HCl patch transdermal drug delivery systems with
the most excellent penetration. Transdermal drug delivery can be efficiently
used for the active agents which undergo rapid first pass metabolism and oral
absorption is often disrupted by nausea and vomiting, hence the transdermal
patches of promethazine HCl were prepared by using different penetration
enhancers, propylene glycol, oleic acid
and isopropyl alcohol. The prepared formulations were evaluated for thickness,
weight variation, moisture content, drug content, morphology, and in vitro
permeation studies. The patch morphology studies were performed by Scanning
Electron Microscopy (SEM). The amount of promethazine HCl transfered by
propylene glycol 25.77 ± 3.0396 ug,
isopropil alcohol 25.758 ± 2.9022 ug and oleic acid 25.017 ± 8.1300 ug. The
penetration of promethazine HCl patch with oleic acid enhancer, produce the
highest penetration than isopropil alcohol and propylene glycol. there was no
difference in penetration using propylene glycol and isopropyl alcohol. Oleic
acid is the best enhancer for preparations patch containing promethazine HCl
although the amount of promethazine HCl contained is the least. The whole
formulations comply with the patch
dosage requirements
Keywords: patch, prometazin HCl, penetration enhancer, transdermal
Penulis: Dwi Nurahmanto
Kode Jurnal: jpfarmasidd160468
