Pengembangan Dan Validasi Metode Analisis Tablet Furosemid Dengan Metode Absorbansi Dan Luas Daerah Di Bawah Kurva Secara Spektrofotometri Ultraviolet
Abstrak: Development and
validation of analysis methods of furosemide tablet have been done by
absorbance method and area under the curve methods using ultraviolet
spectrophotometry. Linearity of pure furosemide was obtained with range
concentration 8 - 18 ppm. Coefficient correlations absorbance and area under
curve methods were 0.99999 and 0.99725 respectively. The percentage of stated
content were determined, which were compared with Gralixa Furosemide tablets
and generic furosemid tablets. The results showed that the percentage of stated
content from Gralixa tablet with absorbance and the area under curve methods
were 99,33 % ± 0,004 and 98,44 % ± 0,003 and the recovery were 98,75 % and
97,88 % respectively. While the research results showed that the percentage of
stated content from generic furosemide tablets with absorbance and area under
curve methods were 98,42 % ± 0,005 and 97,78 % ± 0,008 and the recovery were
98,61 % and 95,06 %. Statistical analysis proves that the method is
reproducible and selective for the analysis of furosemide.
Kata Kunci: Furosemide Tablet;
Absorbance method; Area Under Curve Methode; Ultraviolet Spectrophotometry
Penulis: Ridho Asra, Harrizul
Rivai, Via Lovita Riani
Kode Jurnal: jpfarmasidd160619
