PENGEMBANGAN TABLET EFERVESEN KOMBINASI BROKOLI DAN PEGAGAN DENGAN KOMBINASI ASAM DAN BASA
ABSTRACT: Brocoli and pegagan
is a plant that is easy to get and efficacious as antidemensia. The objective
of this study was to formulate the plant into an effervescent tablet
preparation and to determine the best formula with acid concentration
variation. Dry extract of brocoli and pegagan is made by the method of escape
then dried with vacuum dryer. The preparation is made by wet granulation method
of 3 formula with weight of 4 gram per tablet. The granule test includes
moisture content. Result of granule water content ˂5%. Granules are printed in
special chambers and conditions and tested for quality. The result of uniform
weight test of all formula meets the requirements of Pharmacopoeia Indonesia
III; Hardness of tablets 12.06-12.52 kP; Friability of tablets 0.083-0.74%;
Test of dissolution time of efervesen tablet ˂ 5 minutes. Preferred test
results showed formula III with citric acid concentration: 1: 2 tartaric acid
most preferred. ; Test result of asiatikosida content of pegagan extract is
0.08% and efervesen 0.005% tablet; Test results for vitamin C content of
broccoli extract 13.859% and efevesen tablet 16.995%. The results of the
physical quality test of effervescent tablets showed that the three formulas
met the specified requirements. Stability test results for 8 weeks showed that
the effervesen tablet of formula 3 met the requirements of physical quality
during storage.
Keywords: Brocoli, Pegagan,
Effervescent Tablets, Antidemensia
Penulis: Yuliana Kusumawati,
Erni Rustiani, Almasyuhuri
Kode Jurnal: jpfarmasidd170408
