Potency of (Poly) Acrylic/Carboxymethyl Starch-Chitosan Biohydrogel for Curcumin Oral Delivery Matrix
Abstract: Biohydrogel has
gathered great interest in the pharmaceuticals field. This natural polymers
were biodegradable, non-toxic, biocompatible, and its specific ability to
response environment change can be considered for the controlled released
matric of bioactive compound. In this study, the biohydrogel was synthesized by
graft-copolymerization of acrylic acid onto carboxymethyl starch (CMS) and
chitosan. The objective of this research was to determine the effect of CMS-chitosan
ratio on the biohydrogel characteristic. Methods: The acrylic acid was grafted
on to the backbone (3:1) by using cerric ammonium nitrate as the inisiator. A
standarded curcumin was applied to test the binding potency of matrix. Results:
A higher CMS ratio in the polymer mixture (4:1) revealed the highest swelling
power (16.9 w/w) and percentage of curcumin absorption (17.34%). All the
samples have the pH-responsive swelling properties, with the swelling trend was
observed in the order of distilled water > HCl solution > phospathe
buffer solution. FTIR spectra and SEM micrographs has confirmed the
graft-copolymerization of PAA/CMSCs biohydrogel by describing the appearance of
peak around 1600 cm-1 and the morphology of granula structure, respectively.
Conclusion: The graft-copolymerization of acrylic acid onto the two anionic
natural polymer by cerric ammonium nitrate as the initiator has resulted a
pH-dependent swelling biohydrogel, and it has the ability to deliver curcumin
in stomach-targeted system.
Keywords: acrylic acid;
biohydrogel; carboxymethyl starch; chitosan; curcumin
Penulis: Eka Ruriani, Djumali
Mangunwidjaja, Nur Richana, Titi Candra Sunarti
Kode Jurnal: jpfarmasidd180192
