Potensi Ekstrak Etanol Daun Petai (Parkia speciosa Hassk.) Terhadap Kadar Superoksida Dismutase (SOD) pada Plasma Tikus yang Mengalami Stres Oksidatif
Abstract: Cigarette smoke is
free radicals superoxide resources that contains, hydrogen peroxide, hidrosil
and peroksil. Superoxide dismutase (SOD) is an enzymatic antioxidant that
protect cells from oxidative stress by catalize superoxide dismutase (O2*) into
O2 and H2O2. The aimed of this study was to determine the potential of
ethanolic extract of petai leaves against plasma SOD enzyme activity in animals
that was exposed by cigarette smoke. The extract was made by maseration method
using ethanol 96%. Thirty-six rats Sprague Dawley strain were divided into six
groups: normal group was not given
treatment, negative group received 10% CMC-Na, positive control group received
vitamin E, and treatment group received ethanolic extract of petai leaves 50;
100; 250 mg/kgBW of mice. All rats were treated for 14 days. SOD activity was
measured by UV-Visible spectrophotometer at a wavelength of 505 nm. Statistical
analysis using One Way ANOVA. The mean value of SOD activity for normal, negative
control, positive control and the group receiving the ethanolic extract of
petai leaves dose of 50; 100; 250 mg/kg in a row is 37.979 ± 3708; 59.932 ±
3085; 48.552 ± 1234; 57.239 ± 2102; 50.774 ± 1632; 59.124 ± 4849. The result
showed ethanolic extract of petai leaves affected on the activity of SOD was
dose of 100 mg/kg.
Keywords: Parkia speciosa
Hassk., superoksida dismutase, oxidative stress, cigarette smoke
Penulis: Ruth Haryanti
Butarbutar, Robiyanto , Eka Kartika Untari
Kode Jurnal: jpfarmasidd160722
