PREPARATION AND CHARACTERIZATION OF CO-CRYSTALS OF DIACEREIN
Abstract: Diacerein,
anti-inflammatory drug used in the treatment of osteoarthritis. Being a BCS
class II drug, it has poor solubility, dissolution rate and other
physicochemical properties. Thus the aim of present study was to prepare
co-crystals of diacerein to improve solubility, dissolution rate. The diacerein
co-crystals were prepared using urea and tartaric acid as conformer by Solvent
drop grinding method. The diacerein co-crystals were characterized by scanning
electron microscopy (SEM), FT-IR spectroscopy (FT-IR), Differential scanning
calorimetry (DSC) and X-ray diffractometry (XRD). The co-crystals were
evaluated for solubility, dissolution rate and other physicochemical properties
and compared with commercial diacern sample. The co-crystals exhibit the
difference in the size and shape of crystals. The FT-IR spectra of diacerein
co-crystals showed slightly different in the characteristic peaks compared to
commercial diacerein sample. DSC data indicate the decrease in the melting
endotherm of co-crystals compare to diacerein. The co-crystals with urea showed
increase and intense peak and co-crystals with tartaric acid showed decreased
number of peaks compared to commercial diacerein. The co-crystals of diacerein
formulated in to the Tablet and evaluated for tablet properties. The tablet
formulation showed improved tablet characteristics as well as dissolution rate
compared to commercial diacerein.
Keywords: Co-crystals;
Diacerein; physicochemical properties; FT-IR
Author: Raju Rameshrao Thenge,
V B Patond, P V Ajmire, L N Barde, N M Mahajan, N P Tekade
Journal Code: jpfarmasigg170011
