Reversibility Time in Testicular Damage on Male Wistar Rat after Treatment of Averrhoa blimbi L. Fruits Extract as Antifertility
Abstrak: Belimbing wuluh
(Averrhoa blimbi) fruit is commonly used traditionally as antifertility. The
bioactive compounds of A. blimbi have been known could inhibit spermatogenesis
and development of testes, as well as decrease the quality and quantity of
spermatozoa, thus, caused seminiferous tubular atro- phy. This study aimed to
determine the reversibility time in testicular damage after the treatment of A.
blimbi fruit extract on male Wistar rat. The method employed a completely
randomized design (CRD) consists of nine treatments with three replications
each. The treatment of the extract at a dose 1140 mg/ kg BW and control group
was given the solvent. After 14 days of treatment, the reversibility time was
examined in testis histological section by interval of seven days each until 49
days. The results showed that the treatment of A. blimbi fruit extract caused
disruptions in seminiferous tubules, i.e. decreased the number of
spermatogonium and spermatid, as well as the diameter of lumen and seminiferous
tu- bules. The reversibility time was observing at 21 days after the end
extract treatments, by increasing the number of of spermatogonium and
spermatid, as well as the diameter of lumen and seminiferous tubules that signi
cantly different with infertile rat (p<0.05). In conclusion, the
reversibility time was 21 days after the treatment of A. blimbi fruit extract
as antifertility.
Key words: Averrhoa blimbi,
rats, reversible time, tubulus seminiferous
Penulis: Kartiawati Alipin,
Indra A. Rochman, Desak M. Malini, Madihah
Kode Jurnal: jpfarmasidd180233
