Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas
Abstract: Liver cirrhosis has
become the international health problem that causes significant mortality.
Handling using herbs from various countries has been done, one of them by
consuming roselle (Hibiscus sabdariffa) calyx extract. H. sabdariffa contains
anthocyanins, flavonoids, tannins, and ascorbic acid that function as
hepatoprotector. H. sabdariffacalyx extract may inhibit the increasing of
various clinical parameters, such as ALT, AST, ALP, and LDH in various inducer
types, ie acetaminophen, CCl4, CdCl2, DNPH, and TAA. The mechanism of action of
H. sabdariffacalyx extract are as an antioxidant, inhibition of cytochrome
enzyme, induction of phase II metabolism enzymes, increase cell viability
percentage, increase CAT, GSH and decrease protein expression of pJNK, tBid and
Bax. However, the consumption of H. sabdariffacalyx extract may also cause
acute, subchronic, and chronic toxicity depending on the given dose.
Keywords: Hibiscus sabdariffa,
roselle, hepatoprotective, toxicity
Penulis: Steffi Liem, Jutti
Levita
Kode Jurnal: jpfarmasidd170565
