ROLE OF CHITOSAN, CARBOXY METHYL CELLULOS, POLYVINYL PYRROLIDONE, KYRON T134 AND PRIMOGEL TO DESIGN THE MOUTH DISINTEGRATING TELMISARTAN TABLET WITH EXTENDED RELEASE PROFILE
Abstract: The Mouth
Disintegrating Extended Release Telmisartan (MDERT) tablets are designed for
adequate pharmacokinetic profile to avoid the unusual peaks and troughs.
Although, there are extensive advance techniques used to deliver drugs. But
oral route is still remains effective in most of the therapeutical situations.
Thus we aimed this study to formulate a dosage form with dual character of
orodispersion as well as extended effectiveness. MDERTS dosage form was
prepared by direct compression method. The major components of this preparation
were Telmisartan (TLM), Carboxy methyl cellulose polyvinyl Pyrrolidone,
Chitosan, Talc, Mg-stearate, Lactose. The MDERTS dosage form was characterized
with different determinants. While, the drug release curves of all 6
formulations upto 12h, DSC spectra of TLM, Kyron T134, Primogel, TLM+Kyron
T134+Primogel, Chitosan, CMC and different excepients are presented as
comprehensive scientific figures. DSC and FTIR spectroscopic studies indicate
the compatibility of drugs with each other and with excipients. Moreover, the
formulation F2 containing more than 10% of Kyron T had shown best results.
Whereas, the overall results had shown that Kyron T containing tablets had
best, in vitro dispersion time, wetting time and wetting volume, water
absorption ratio. The order in which superdisintegrants and polymers had
produced desirable effect is Kyron T134 > Kyron T134134 + primogel > primogel and for
polymers chitosan> chitosan+CMC> chitosan +PVP> CMC> CMC+PVP>
PVP. Thus, Kyron T is the best superdisintegrant of others which were used in
present study and direct compression method is the best used to prepare
extended release mouth disintegrating tablets.
Keywords: Chitosan, CMC, PVP,
Kyron T134, Primogel TLM, MDERT’s
Author: Muhammad Abdullah
Akram, Nida Taha, Taha Nazir
Journal Code: jpfarmasigg170001

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