SKRINING AKTIVITAS ANTIMALARIA BEBERAPA TANAMAN INDONESIA HASIL EKSPLORASI DARI HUTAN RAYA CANGAR, BATU-MALANG, JAWA TIMUR
ABSTRACT: Malaria is the most
important parasitic disease. Malaria control which depends on specific
chemotherapy now complicated by resistance of Plasmodium falciparum to most
commonly available antimalarial drug. Such situation has heralded the need for
alternative antimalarial therapy. Objective: This research aim was to find new
antimalarial candidates from some Indonesia plants collected from Cangar
National Forest, Batu-Malang, East Java. Methods: Eleven samples of leaves and
stem extracts were screened against Plasmodium falciparum 3D7 culture which
maintained in RPMI-1640 Medium. Samples tested in concentration of 0.01, 0.1,
1, 10 and 100 µg/ml. Probit analysis was used to determine IC50. Results: In
vitro antimalarial activity revealed that only three crude extracts samples
from Fraxinus griffithi stem extract, Piper sulcatum leaves extract and
Eucalyptus globulus stem extract had good antimalarial activity with IC50 value
of 0.33, 0.20 and 0.55 µg/ml, respectively. Conclusions: Fraxinus griffithi
stem extract, Piper sulcatum leaves extract and Eucalyptus globulus stem
extract might be a good candidate for antimalarial natural product resources.
KEYWORDS: antimalarial
activity, in vitro, plasmodium falciparum, plant extracts
Penulis: Achmad Fuad Hafid,
Nike Puliansari, Nur Suci Lestari, Lidya Tumewu, Abdul Rahman, Aty
Widyawaruyanti
Kode Jurnal: jpfarmasidd160726
