STUDI KEMAMPUAN PATI BIJI ALPUKAT (Persea americana Mill) PREGELATINASI SEBAGAI BAHAN PENGHANCUR PADA TABLET PARACETAMOL KEMPA LANGSUNG
Abstrak: Researched about the
study of the ability of pregelatinized avocado seeds (Persea americana Mill)
starch as disintegrant by direct compression of paracetamol tablets
formulation.This Research suppose to know about the ability of pregelatinized
avocado seeds starch as disintegrant and optimum concentration of
pregelatinized avocado seeds starch as disintegrant on direct compression
fulfill the qualification good tablets.
Pregelatinized starch produced by heating in its gelatinated temperature,
next dried and standardized its measure. Then, evaluated according to granul
evaluation. Mixing the mass of tablets, Three formulas were made by
disintegrants concentration different (pregelatinized avocado seeds starch) FI
5%, FII 10% dan FIII 15%. Next, evaluated. Tablets compressed by direct
compression method and evaluated.
The evaluation results pregelatinized avocado seeds starch regularly have
particle size 231,3μm, angel of repose 22,76o, fluidity 7,40/det, density true
1,21g/ml, density bulk 0,68 g/ml, density tapped 0,72 g/ml, porosity 40,84 %,
compressibility index 3,77%, hausner’s ratio 1,03 and LOD 0,39%. The result
show that pregelatinized avocado seeds starch have a good compressibility and
fluidity. Result test for tablets show all formulas fulfill the qualification
the tablets size uniformity, FII dan FIII fulfill the qualification at the weights
uniformity, its hardness regulary 4,51 kg; 6,39 kg; 4,23 kg, friability 1,4%;
0,07%, and 1,50% and disintegration time 0,27 minute; 0,44 minute and 0,04
minute.
From this result can be concluded that the pregelatinized avocado seeds
starch can be used as a disintegrant on direct compression and the optimum
concentration on direct compression pregelatinized avocado seeds of the produce
tablets fulfill the qualification a good tablets is FII (10%).
KATA KUNCI: Tablets.,
Paracetamol., pregelatinized avocado seeds starch., disintegrant., direct
compression
Penulis: Surya Ningsi, Dwi
Wahyuni Leboe, Qurratul Aeni
Kode Jurnal: jpfarmasidd160693
