STUDI PELEPASAN SENYAWA POLIFENOL EKSTRAK DAUN SIRIH (PIPER BETLE L.) MATRIK PATCH MUKOADESIF METHOCEL® A15
Abstract: Mucoadhesive patch
is systemic circulation drug delivery system. The drug is placed on gingival or
buccal. The drug release is controlled by the polymer. This research was aimed
to determine the effect of PEG 400 as a plasticizer and Menthol as a permeation
enhancer to release of polyphenol compound. Simplex Lattice Design (SLD) was
used to determine the effect of PEG 400 and Menthol by placed the Efficiency
Dissolution percent (%DE) as a response. The result showed a special cubicÂ
equation, y=4,40674(A) +5,05156(B)+4,92658(AB)+4,01144AB(A-B). PEG 400 and
Menthol component both synergistic gave a positive effect to the polyphenol
release of the mucoadhesive patch. ANOVA test showed the probability value of
its equation of 0,0223 (p<0,05). It means the response of each formula is
significantly different. The formula was generated by composition of PEG 400
and Menthol (1,5:0,5) exhibit the higest %DE of 15,23%. The coefficient
correlation value (R) of formula that generated from Korsmeyer-Peppas equation
is 0.985 and the flux of 0.997 mg/jam.cm2. The release mechanism is following
Fickian, which the diffusion is slower than relaxation.
Keyword: PEG, menthol, drug
release, polyphenol
Penulis: Eka Indra Setyawan,
Putu Oka Samirana, Putu Eka Masmita U.D., I Gusti Ngurah Agung D.P.
Kode Jurnal: jpfarmasidd170572
