Studi Sistem Dispersi Padat Asam Mefenamat Menggunakan Polivinilpirolidon K-30
Abstrak: Mefenamic acid was
categorized as Non-Steroidal Anti-Inflamatory Drugs (NSAIDs) which has useful
as analgesic, anti inflammatory, and antypiretic effect but it has poor
solubility in water. The aim of this study was to increase the dissolution rate
of mefenamic acid in a solid dispersion system which made by solvent method.
Solid dispersion and physical mixture prepared with ratio 1:1, 1:3, and 1:5.
Solid dispersion was prepared by solvent method Preparation of solid dispersion
mefenamat acid – PVP-K30 in formula 1:3 was increased of dissolution
significantly. Characterization of Solid
dispersion Mefenamic Acid with Polyvinylpyrrolidone used Scanning Electron
Microscopy (SEM), X-Ray, Spectroscopy IR, Differentyal Thermal Analysis (DTA).
The result of X-ray diffraction characterization the dissolution Mefenamic
Acid-Polyvinylpyrrolidone in which the intensity is visible. The
characterization with DTA showed a change in the peak of Mefenamic Acid where
the endoterm, the characterization using infrared spectroscopy shows no
functional group interaction between Mefenamic Acid and Polyvinylpyrrolidone.
Kata Kunci: Solid dispersion;
mefenamic acid; polyvinylpyrrolidone
Penulis: Maria Dona Octavia,
Erizal Zaini, Vina Oktavia
Kode Jurnal: jpfarmasidd150615
