STUDI TERATOGENIK PEMBERIAN TRITERPEN TOTAL DARI Centella asiatica (Linn) Urban PADA MENCIT PUTIH
ABSTRACT: The main active
compound of the Centella asitica (Linn) Urban is total triterpenic. Total
triterpenic has been proven to be effective in inflamatorry, infection and
diabetic to patient. To examine its safety in pregnancy condition, the
influence of total tripenic of Centella asitica had been studied in pregnant
Wistar mice. The total tripenic of Centella asitica were administered orally at
dose level of 20 mg/kgbw, 40 mg/kg bw , 80 mg/kgbw on day sixth to fifteenth of
gestation. The mother was sacrified on day eightteenth of gestation to observe
life fetus, resorption, and fetus bodyweight. One third of the fetuses
eviscerated for skeletal staining with alizarin red and two third of the
fetuses were hardened with Bouin’s fixation solution. No malformation were
found in the eviscerated group. The at all doses did not cause any fetus
resorption, did not cause malformation in organ and skeleton but cause fetus
growth failure.
Key words: teratogenicity
study, total triterpenic, Centella asiatica
Penulis: Erjon
Kode Jurnal: jpfarmasidd180086
