THE EFFECT OF PASAK BUMI ROOTS TOWARDS BLOOD GLUCOSE LEVEL IN GLUCOSE-LOADED MICE
Abstract: The aim of this
research is to evaluate the effect of pasak bumi roots (Eurycoma longifolia
Jack) towards the blood glucose level in glucose-loaded mice. The blood
glucose-lowering effects were tested using Oral Glucose Tolerance Test (OGTT)
method. The mice were given with infusion of pasak bumi roots at the doses of
0.83; 1.67; 3.33 g/kgBW and methanol extract of pasak bumi roots at the doses
of 102; 210; 420 mg/kgBW. All treatments were conducted orally, 30 minutes
before the administration of glucose (2 g/kgBW). The blood glucose levels were
measured at 0 minute before the administration of glucose and at 15, 30, 60,
90, and 120 minutes after the administration of glucose. Blood samples were
obtained through the mice tail’s vena lateralis using glucometer. The blood
glucose levels result which were obtained at the 0 until 120 minutes were
calculated to obtain AUC. AUV values of each treatment group were analyzed
statistically. Based on the results of the research, it can be concluded that
the methanol extract of pasak bumi roots has blood glucose-lowering effect at
the doses of 210 and 420 mg/kgBW, but infusion of pasak bumi roots does not
have effects on lowering the blood glucose level in the glucose-loaded mice.
Keywords: blood glucose;
Eurycoma longifolia Jack; oral glucose tolerance test
Penulis: Fransisca, Gracia
Easter Kalangi, Damiana Sapta Candrasari, Phebe Hendra
Kode Jurnal: jpfarmasidd180169
