The Effects of Dual Antiplatelet Post Percutaneous Coronary Intervention on Percentage of Aggregation In Myocardial Infarction Patients with Diabetes Mellitus and Non Diabetes Mellitus
ABSTRACT: To analyze the
differences in the effect of dual antiplateletpost PCI on the percentage of
aggregation in myocardial infarction patients with DM and non DM. Percentage of
aggregation were analyzed using light transmission aggregometry (LTA) before
loading dose, after PCI, and after maintenance dose of dual antiplatelet
(aspirin 100mg and clopidogrel 75mg). Total 22patients were participated in
this study divided into 10 and 12patients in diabetic and non diabetic group.
Percentage ofaggregation after taking dual antiplatelet maintenace dosedecrease
significantly in both group (p=0.006 in diabetic group and p=0.002 in non
diabetic group). Mean reduction of percentage of aggregation in diabetic group
(3.30±2.91%) is lessthan non diabetic group (6.83±5.97%). Statistical analysis
showsthat the mean reduction of percentage of aggregation betweentwo groups
were not significantly different (p>0.05). Meanpercentage of aggregation
after dual antiplatelet maintenancedose was higher in diabetic group and mean
reduction ofpercentage of aggregation was higher in non diabetic group, although
statistically in both group it is not significantly different.
Keyword: Myocardial
infarction, Diabetes Mellitus, Dual antiplatelet, Aspirin and Clopidogrel,
Percentage of aggregation
Author: Yessi Asli Rahmawati,
Mohammad Yogiarto, Bambang Subakti Zulkarnaen
Journal Code: jpfarmasigg180002
