UJI AKTIVITAS ANTIBAKTERI FORMULASI GEL UNTUK SARIAWAN DARI EKSTRAK DAUN SAGA ( Abrus precatorius Linn. ) TERHADAP BAKTERI Staphylococcus aureus
Abstract: One of plants used
by Indonesian people as a traditional medicine is saga plant (Abrus precatorius
L.). This plant has medicinal properties as medication for thrush, cough and
laryngitis. Chemical constituents contained in sage leaves which work as
antibacterial are flavonoid and saponin. This study aims to determine the
optimal concentration of saga leaves extract which can be formulated in a gel
dosage form with qualified physical evaluation and has antibacterial activity
against Staphylococcus aureus. Saga leaves extract is prepared by maceration
method using ethanol 70% as solvent, and then the extract obtained is
preliminarily tested to see its antibacterial activity against Staphylococcus
aureus with agar diffusion method. Gel formulation for thrush is made with
dispersion method in three formulas with variants of active substance
concentration that is FI (1%), FII (3%) and FIII (5%). Gel preparation
antibacterial activity test is conducted with agar diffusion method as a plate
cylinder. Based on this research, it was found that the extract of saga leaves
which is positively made is efficacious as antibacterial and can be formulated
into a gel preparation for thrush with optimal concentration in F III (5%),
this is indicated by widest diameter of the inhibition area against
Staphylococus aureus bacteria
Keywords: saga leaves, gel,
antibacterial activity
Penulis: Ratih Dyah Pertiwi,
Joni Kristanto, Graha Ayu Praptiwi
Kode Jurnal: jpfarmasidd160472