UJI AKTIVITAS ANTIBAKTERI SECARA IN VIVO EKSTRAK ETANOL DAUN PAKIS SAYUR (Diplazium esculentum Swartz) PADA MENCIT JANTAN GALUR BALB/C YANG DIINFEKSI Salmonella typhi ATCC 14028
Abstrak: Vegetable fern leaf
(Diplazium esculentumSwartz) is kind of plant that can inhibit Salmonella typhi
growth. The study aimed to determine the effect of vegetable fern leaf
ethanolic extract on male mice that had been infected by Salmonella typhi
bacteria. Vegetable fern leaf powder was macerated with 95% ethanol and was evaporated with vacum
rotary evaporator. Dosage variation of vegetable fern leaf ethanolic extract on
male mice were (100; 200; 300; 400 and 500 mg/kgbb). Blood of male mice veins
was cultured on agar media and counted
bacterial colonies that were formed. Study result showed increasing of
vegetable fern leaf ethanolic extract could decrease the colony of Salmonella
typhi that infected in male mice. Vegetable fern leaf ethanolic extract with
500 mg/kgbb could decrease 6,21% of Salmonella typhi in male mice. vegetable
fern leaf ethanolic extract with dosage variation not significantly decrease the amount of bacteria colonies in
mice. Compound identification by thin layer chromatography (TLC) showed
vegetable fern leaf ethanolic extract contained of flavonoids, saponins, alkaloids, tanins and
terpenoids.
KATA KUNCI: antibacterial.,
Diplazium esculentum S., Salmonella typhi
Penulis: Wahyuni, Fery
Indradewi Armadany, Mirna Widasri
Kode Jurnal: jpfarmasidd160701
