UJI AKTIVITAS EKSTRAK ETANOL 96% BIJI SRIKAYA (Annona squamosa L.) SEBAGAI ANTIDIARE YANG DISEBABKAN OLEH BAKTERI Shigella dysenteriae DENGAN METODE DIFUSI CAKRAM
Abstract: This research aims
to find out how to extract ethanol 96% seed custard apples as Antidiarrhoeal
that is caused by bacteria Shigella dysenteriae with different concentrations
and compare with chloramphenicol. In addition, also to find out whether their
respective inhibitory power of concentration of ethanol 96% seed extract
custard apples have a difference in meaning. Research done by experimental
methods, was carried out in the laboratory of pharmaceutical Academy IKIFA.
Testing was done using the diffusion disc method. The concentration of ethanol
96% seed extract custard apples are used i.e. 15%, 30%, 45%, 60%, and 75%. As
positive controls used chloramphenicol 30 µg/ml and NaCl 0.9% as the negative
control. Each test is carried out as many as eight repetitions. The results
showed an average diameter drag power which formed on the test solution with a
concentration of 15%, 30%, 45%, 60% and 75% respectively of 6,887 mm, 11,49 mm,
8,144 mm, 7,694 mm, 7,150 mm, whereas for chloramphenicol for 40,31 mm. Based
on the results of the statistical tests there are meaningful differences
between concentrations showed a meaningful difference between the concentration
of 15% and 30%, 15% and 60% and 15% and 75%. Conclusion of this research is at
a concentration of 15%, 96% ethanol extract of seeds of custard apples have
been able to inhibit the growth of bacteria, Shigella dysenteriae
Keywords: Custard apples seed
(Annona squamosa L), antidiare, Shigella dysenteriae, disc diffusion method
Penulis: Leonov Rianto
Kode Jurnal: jpfarmasidd150541
