UJI AKTIVITAS EKSTRAK ETANOL GAMBIR (Uncaria gambir Roxb.) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT PUNGGUNG MENCIT PUTIH JANTAN (Mus musculus)
Abstract: Gambir (Uncaria
gambir Roxb.) contains flavonoids, tannins, saponins and alkaloids that can
help in the healing process of burns on the back skin of mice. Gambir has been
used for the treatment because it has the effect of antimicrobial and
anti-inflammatory. Gambir is used by the people as a traditional medicine to
treat burns.This research is experimental research. The object studied is the
potential of gambir extract on healing burns of mice back skin. The number of
mice used are 15 which divided into 5 groups: the positive control group
(branded ointment), negative control group (vaseline flavum), group of gambir
ethanol extract and vaseline flavum concentration of 25%, 35%, and 45%. Each
group consisted of 3 mice.Backs of the mice induced using a heated solder which
tip contained stainlees plate measuring 1x1 cm and placed for 2 seconds on the
back skin of mice. The percentage of burns healing is obtained by calculating
the surface area of the wound. The data were analyzed using ANOVA analysis
followed by LSD test. The results showed that ethanol extract of gambir
concentration of 25% with the healing burns percentage of (72.00%), the
concentration of 35% (85.00%), and the concentration of 45% (88.67%) have
activity on healing burns of back skin of mice. The results of data analysis
using ANOVA showed that the data has significant differences with a
significance value <0.05 is 0.000. LSD test results stated that each
treatment group have significant differences with a significance value
<0.05. It can be seen that with increasing dose will be followed by duration
of burns healing
Keywords: ethanol extract of
gambir, burns, wound surface area
Penulis: Fitri Handayani
Kode Jurnal: jpfarmasidd150533
