Uji Aktivitas Ekstrak Herba Sambiloto (Andrographis paniculata (Burm.f.) Ness) Terhadap Kadar Nitrogen Monoksida Pada Mencit Putih Jantan Hiperkolesterolemia
Abstrak: Effect of extract of
bitter herbs (Andrographis paniculata (Burm.f.) Ness) has conducted research on
the levels of NO in hypercholesterolemic male white mice. Hypercholesterolemia
was induced by high-fat foods and propylthiouracil. Bitter herbs extract was
administered orally every day for 60 days with a dose of 25 mg/kg BB, 50 mg/kg
BB, and 100 mg/kg BB. The negative control group was only given regular meals
and a positive control group was given a high-fat foods and propylthiouracil.
Parameters measured were the levels of NO in serum. The results showed that the
extract of bitter herbs can increase blood levels of NO white male mice when
compared to the positive control (hypercholesterolemia), but still lower than
the negative control (normal animals) (P<0.05). While the old factor does
not affect the administration of organ weight ratio of the heart, liver and kidneys
and significantly (P>0.05).
Kata Kunci: Sambiloto; Nitric
Oxide; Hypercholesterolemia
Penulis: Aried Eriadi, Suhatri,
Nindywaii Honolhulu
Kode Jurnal: jpfarmasidd170355
