Uji Dissolusi Terbanding Tablet Metilprednisolon Generik Bermerek dan Generik Berlogo Dibandingkan Dengan Tablet Metilprednisolon Paten
ABSTRACT: Generic drugs are
drugs that have expired patents and then can be produced by different
industries from innovator companies. Controversy over the use of drugs Patents
/ original drugs and generic / copy drugs have been ongoing in society,
including health practitioners, although research on the pharmaceutical and
pharmacokinetic phases has been widely practiced. In biopharmaceutical studies,
different formulations and drug production processes can affect the
availability of drugs in the blood which in the later stages will affect the
effects of the drug. This study aims to study the dissolution of
methylprednisolone 4 mg branded generic tablets from drug manufacturers PT.B,
generic “berlogo” from PT.I and patent product from PT.P. Dissolved content was
measured using a UV-Vis spectrophotometer at a wavelength of 200-400nm. The
dissolution profile showed no significant difference for patent / innovator,
generic branded and generic “berlogo” with similarity factor (F2) patent
product with branded generic is 86,9 and patent product with generic logo is
81,2, so it can be concluded that the dissolution profiles of these three drugs
are the same.
Kata kunci: metilprednisolon; generik; paten; disolusi
Penulis: Hansen Nasif, Erizal
Zaini, Agnes S
Kode Jurnal: jpfarmasidd170133
