Uji Efek Ekstrak Etanol Daun Sirsak (Annona muricata L.) terhadap Aterosklerosis Arteri Koroner Burung Puyuh Jantan
Abstrak: Has been research
about influence of ethanol extract of leaves of soursop (Annona muricata L.) on
the formation of coronary artery atherosclerosis of male quail induced high fat feeding and propylthiourasil. Male
quail were divided into five groups , each group getting treatment. Negative
controls given standard diet, a positive control was given high fat feeding and
propylthiouracil, doses of 50, 100, 200 mg / kg BW ethanol extract administered
orally soursop leaves. The treatment is done for 60 day, then take heart, be
making preparations histopathology and staining haematoxyllin-eosin. The
results showed that the ethanol extract of leaves of soursop dose 50 mg / kg BW selective in preventing
atherosclerosis in male quail, when compared with the positive control ( P <
0.05 ). While the administration at a dose of 100 and 200 mg / kg showed no
selective in preventing atherosclerosis in male quail, when compared with the
positive control .
Kata Kunci: Extract leaves;
Annona muricata; atherosclerosis
Penulis: Zet Rizal, Surya
Dharma, Rusmayanti
Kode Jurnal: jpfarmasidd150606