Uji Efek Teratogen Ekstrak Etanol Daun Sirsak (Annona muricata L) Terhadap Fetus Mencit Putih
Abstrak: Research on test
teratogenic effects of ethanol extract
of leaves of the soursop (Annona muricata L.) have been conducted on white mice
fetus. Animal experiments are grouped into
4 group consisting of Group I as a negative control only granted
suspension of Na CMC 0.5%, Group II, Group III and Group IV granted soursop
leaf ethanol extract at a dose of 250 mg / kg, 500 mg / kg, and 1000 mg / kg
once daily from day 6 to day 15 of pregnancy. The 18th day of pregnancy mice
were dissected. Results of the study at a dose of 250 mg / kg, a dose of 500 mg
/ kg, a dose of 1000 mg / kg give teratogen effects. A dose of 250 mg / kg, a
dose of 500 mg / kg give teratogen effect with the discovery of skeletal
abnormalities. A dose of 1000 mg / kg give teratogen effect with the discovery
of late growth. Results showed that the ethanol extract of the leaves of the
soursop affect weight loss parent mice were significantly (p <0.05) when
compared to the negative control. The quantity of fetuses decreased
significantly (p <0.05) when compared to the negative control. Fetal body
weight showed a significant effect (p <0.05) when compared to the negative
control.
Kata Kunci: Extract Annona
Muricata; White Mice; Teratogenic
Penulis: Ifora, Suhatri, Suzie
Yolandha
Kode Jurnal: jpfarmasidd160611
