UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN KEREHAU (Callicarpa longifolia Lam.) TERHADAP MENCIT PUTIH
Abstract: Leaves kerehau
(Callicarpa longifolia Lam.) is one of the plants used for the treatment of
malaria, ulcers, diarrhea, treatment after delivery, and fever, by drinking
boiled water. Report usage and security kerehau leaves are still very few. The
purpose of this study to determine the potential for acute toxicity by
determining the value of LD50 (Lethal Dose 50) in 4 dose-rise that dose I, II,
III, and IV of the ethanol extract of the leaves kerehau against this mice. The
Research. Pharmacologically using experimental methods using a completely
randomized design pattern is undirectional in the selection of test animals,
They are 25 mice were divided into five groups (5 mice each group), with
observed 4 hours to determine the toxic symptoms and continued observation
every 24 hours for 7 days to see death. Results from this study show from 4
dose levels, dose group I = 16g / kg, group II = 8g / kg, group III = 4g / kg
and group IV = 2g / kg and control = 0.5 ml Na-CMC. Symptoms namely the
observation of behavior and neuromuscular but not on observations of the
autonomic nervous, respiratory, gastrointestinal, and skin. LD50 value obtained
is expressed by the LD50 (16g / kg) were categorized as practically non-toxic
(> 15g / kg)
Keywords: Callicarpa longifolia Lam , acute toxicity, LD50
Penulis: Eka Siswanto, Desy
Nur Indah Sari, Supomo
Kode Jurnal: jpfarmasidd150532
