Uji Toksisitas Akut Ekstrak Etanol Daun Kirinyuh (Chromolaenodorata (L) R.M.King & H. Rob) Pada Mencit Putih Jantan
Abstrak: A research on the
acute toxicity of ethanol extracts of leaves kirinyuh (Chromolaena odorata (L)
R.M.King & H.Rob). Parameters observed toxicity is LD50 and delayed toxic
effects for 14 days of observation including changes in weight, the volume of water
consumption, and the relative weight of the organs of the heart, liver,
kidneys, stomach and lungs. The extract ethanol leaves kirinyuh (Chromolaena
odorata (L) R.M King & H.Rob) orally at a dose of 4 g/kgBB, 8 g/kgBB and 16
g/kgBB, showed that the ethanol extract of leaves kirinyuh (Chromolaena odorata
(L) R.M King & H.Rob) categorized practically non-toxic (LD50> 15
g/kgBB). Delayed toxic effects are seen from the significant differences in
body weight, the volume of water, relative organ weight of lung and stomach
(P<0.05). There were no significant differences in the relative organ weight
of the heart, liver and kidneys (P<0.05).
Kata Kunci: LD50; delayed
toxicity; Chromolaena odorata (L); R.M.King & H.Rob; the ethanol extract of
leaves kirinyuh (Chromolaena odorata (L) R.M King & H.Rob).
Penulis: Aried Eriadi, Helmi
Arifin, Nirwanto
Kode Jurnal: jpfarmasidd160620
